Key result
Stage I hypertension in men is linked to lower peak VO2 and reduced cardiac output.
Why the study?
Does peripheral vascular resistance limit exercise functional capacity in mild hypertensives compared to healthy controls?
Cross-Sectional (n=35)
Does peripheral vascular resistance limit exercise functional capacity in mild hypertensives compared to healthy controls?
p-value: p=<0.045
Impaired peripheral vascular autoregulation, rather than cardiac output, appears to be the primary driver of reduced exercise capacity in early-stage hypertension.
May suggest vascular resistance limits exercise capacity in early hypertension; hypothesis-generating and should not yet change practice.
To evaluate the physiological basis for suboptimal peak exercise oxygen consumption (VO2p) observed in the early stage of hypertension, 25 WHO Stage I hypertensive men with normal left ventricular mass and 10 healthy control subjects of equivalent age underwent the maximal cardiopulmonary exercise test with contemporary measurement of cardiac output with Tc99m angiocardiography. At peak exercise hypertensive patients had lower VO2p (p < 0.045) and cardiac output (p < 0.014) and higher vascular resistance (p < 0.010) than controls. At multiple regression analysis VO2 was positively related to cardiac output in controls (r = 0.80, p < 0.02), whereas in hypertensives the best (negative) correlation was observed with peripheral vascular resistance (r = -0.72, p < 0.04). Thus reduced cardiopulmonary function during physical exercise in hypertensives seems to be mainly related to impaired peripheral vascular autoregulation.
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Modesti et al. (1999) conducted a cross-sectional in Mild hypertension (n=35). WHO Stage I hypertension vs. Healthy control subjects was evaluated on Peak exercise oxygen consumption (VO2p) (p=<0.045). WHO Stage I hypertension in men was associated with lower peak exercise oxygen consumption (P<0.045) and cardiac output (P<0.014), and higher vascular resistance (P<0.010) compared to healthy controls.
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