Key result
Transgenic murine models elucidate genetics and signaling pathways directing cardiac conduction system development and function.
Population
Transgenic mice models for studying cardiac pacemaking and conduction system development
Design
Review
Authors
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Preclinical mouse models extend genetic insights into conduction system development; clinical translation remains premature.
Transgenic mouse models provide a valuable tool for elucidating the genetic and signaling pathways involved in the development of the cardiac pacemaking and conduction system.
Myers et al. (2004) conducted a review in Murine cardiac pacemaking and conduction system development. Transgenic marker lines and mutants are being used to elucidate the genetics and signaling pathways directing the development and function of the murine cardiac pacemaking and conduction system.
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