Key result
Acute hypertension caused myosin VI to redistribute from low density apical microvilli-enriched membranes (23% to 11.4%) into higher density membranes (23.2% to 36.9%) in rats.
Authors
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May not alter hypertension management; leaves open myosin VI's role in human proximal tubule sodium handling.
Absolute Event Rate: 11.4% vs 23%
Yang et al. (2005) studied Acute hypertension. Acute hypertension vs. Sham treated / controls was evaluated on Myosin VI redistribution from low density apical MV-enriched membranes into higher density membranes. Acute hypertension caused myosin VI to redistribute from low density apical microvilli-enriched membranes (23% to 11.4%) into higher density membranes (23.2% to 36.9%) in rats.
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