November 1, 2002AJP Renal Physiology

Angiotensin II clamp prevents the second step in renal apical NHE3 internalization during acute hypertension

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Population

Anesthetized Sprague-Dawley rats

Comparison

ANG II clamp during acute hypertension vs Acute hypertension without ANG II clamp, or sham…

Design

Preclinical

Follow-up

20 min

Authors

PLPatrick K. K. LeongUniversity of Southern California LYLi E. YangGeneral Hospital of Central Theater Command NHNiels‐Henrik Holstein‐RathlouUniversity of Copenhagen

Discussion

Member takes

Implication

No immediate clinical implications; extends rodent NHE3 trafficking data but leaves open human relevance.

Structured PICO

Population

Anesthetized Sprague-Dawley rats

Intervention

ANG II clamp (simultaneous infusion of captopril 12 microg/min and ANG II 20 ng.kg-1.min-1) during acute hypertension (blood pressure increased 50 mmHg for 20 min by arterial constriction)

Comparator

Acute hypertension without ANG II clamp, or sham operation

Outcome

Redistribution of Na+/H+ exchanger isoform 3 (NHE3) and urine output/endogenous Li+ clearancesurrogate

The full diuretic response and complete intracellular internalization of proximal tubule NHE3 during acute hypertension require a responsive renin-angiotensin system.

Cite This Study

Leong et al. (2002) studied this question.

synapsesocial.com/papers/6a7e7a1db44705ee46857075 https://doi.org/10.1152/ajprenal.00178.2002

View Full Paper

Ask AI

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Angiotensin II clamp prevents the second step in renal apical NHE3 internalization during acute hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II clamp prevents the second step in renal apical NHE3 internalization during acute hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider