Key result
Enalapril induces similar sodium loss in hypertensive patients on low versus liberal sodium diets.
Why the study?
Does enalapril increase sodium excretion in subjects with uncomplicated essential hypertension on low versus liberal sodium diets?
Population
10 subjects with uncomplicated essential hypertension
Comparison
Enalapril 10 mg b.i.d. for 8 days vs Low versus liberal sodium intake
Design
Other
Follow-up
8 days
Authors
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Enalapril may induce diet-independent natriuresis in hypertension; leaves open its mechanistic contribution to enhanced BP reduction with salt restriction.
Does enalapril increase sodium excretion in subjects with uncomplicated essential hypertension on low versus liberal sodium diets?
Enalapril induces a net negative sodium balance and weight loss in patients with essential hypertension regardless of dietary sodium intake, although blood pressure reduction is potentiated by sodium restriction.
Navis et al. (1987) studied uncomplicated essential hypertension (n=10). Enalapril vs. Low vs liberal sodium intake was evaluated on Sodium loss. Enalapril 10 mg b.i.d. for 8 days induced similar net sodium losses of 101 ± 24 mmol and 112 ± 15 mmol in hypertensive patients on low and liberal sodium diets, respectively.
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