Why the study?
Does a 4-day oral salt load increase blood pressure in males with primary hypertension on chronic enalapril treatment?
Population
6 males with primary hypertension, who had attained normotension on chronic enalapril treatment for 4 years
Comparison
4-day oral salt load (150 mmol NaCl extra per day) vs Placebo treatment (two-way cross over)
Design
RCT, randomized, two-way cross over, double-blind
Follow-up
4 days
Authors
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Even brief salt loading raises BP despite enalapril; confirms ongoing sodium restriction need and extends salt-sensitivity data to ACEI-treated hypertension.
Does a 4-day oral salt load increase blood pressure in males with primary hypertension on chronic enalapril treatment?
A short-term oral salt load in hypertensive patients on chronic enalapril treatment causes a significant rise in blood pressure related to cellular sodium transport.
BJÖRN DAHLÖF HANS HERLITZ (1998) studied this question.
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