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Overexpression of the TcRBP19 RNA-binding protein in Trypanosoma cruzi affected the metacyclogenesis process and led to a decrease in the number of infected mammalian cells.
Overexpression of TcRBP19 in Trypanosoma cruzi impairs metacyclogenesis and reduces mammalian cell infection, suggesting a role in the parasite's life cycle progression.
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Supports targeting TcRBP19 to disrupt T. cruzi differentiation; leaves open clinical translation for Chagas disease.
To characterise the trypanosomatid-exclusive RNA-binding protein TcRBP19, we analysed the phenotypic changes caused by its overexpression. Although no evident changes were observed when TcRBP19 was ectopically expressed in epimastigotes, the metacyclogenesis process was affected. Notably, TcRBP19 overexpression also led to a decrease in the number of infected mammalian cells. These findings suggest that TcRBP19 may be involved in the life cycle progression of the Trypanosoma cruzi parasite.
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Pérez‐Díaz et al. (2012) studied Trypanosoma cruzi infection. TcRBP19 overexpression was evaluated on Metacyclogenesis process and number of infected mammalian cells. Overexpression of the TcRBP19 RNA-binding protein in Trypanosoma cruzi affected the metacyclogenesis process and led to a decrease in the number of infected mammalian cells.
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