Key result
Targeted RNA interference screening revealed that proteins with RNA recognition motifs or pumilio domains play roles in regulating mRNA degradation in trypanosomes.
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The study identifies RNA-binding proteins with RNA recognition motifs or pumilio domains as regulators of mRNA degradation in trypanosomes.
Control of gene expression in trypanosomes relies almost exclusively on post-transcriptional mechanisms. Trypanosomes have the normal enzymes for mRNA decay: both the exosome and a 5'-3'-exoribonuclease are important in the degradation of very unstable transcripts, whereas the CAF1/NOT complex plays a major role in the degradation of all mRNAs tested. Targeted RNA interference screening was used to identify RNA-binding proteins that regulate mRNA degradation, and it revealed roles for proteins with RNA recognition motifs or pumilio domains.
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Clayton et al. (2008) studied mRNA degradation in trypanosomes. Targeted RNA interference screening was evaluated on Identification of RNA-binding proteins regulating mRNA degradation. Targeted RNA interference screening revealed that proteins with RNA recognition motifs or pumilio domains play roles in regulating mRNA degradation in trypanosomes.
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