Key result
Essential hypertension showed significant familial aggregation, with a heritability of 49.51% in first-degree relatives and a significantly higher prevalence among first-degree relatives of cases compared to controls (42.64% vs 26.43%).
Why the study?
To explore the familial aggregation and heritability of hypertension in the Han population in Shanghai, China.
What is the familial aggregation and heritability of hypertension in the Han population in Shanghai, China?
Case-Control (n=684)
No
What is the familial aggregation and heritability of hypertension in the Han population in Shanghai, China?
Absolute Event Rate: 42.64% vs 26.43%
p-value: p=<0.001
Essential hypertension exhibits significant familial aggregation and multigene heritability in the Han population of Shanghai, with heritability highest among first-degree relatives.
Supports family history integration in hypertension risk assessment; extends heritability estimates to Han populations in Shanghai.
BACKGROUND: To explore the familial aggregation and heritability of hypertension in Han in Shanghai China. METHODS: According to l:l matched pairs design, 342 patients of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The method of genetic epidemiology research was used to explore the familial aggregation and heritability of hypertension. RESULTS: The prevalence rate of hypertension of first-degree relatives was significantly higher (34.44%) than that of second- degree relatives (17.60%) and third-degree relatives (13.51%) in Han Population in Shanghai China. Separation ratio p was 0.217, and prevalence rate of case group relatives was higher than that of control group relatives. The results showed a phenomenon of familial aggregation in the distribution of hypertension. The heritability of first- degree relatives was 49.51%; that of second-degree relatives and third-degree relatives were respectively 23.42 and 21.41%. CONCLUSION: The distribution of essential hypertension has phenomenon of familial aggregation in Han Population in Shanghai China. The separation ratio of essential hypertension in this study shows that essential hypertension conform to the characteristics of multigene genetic disease. The heritability of first-degree relatives is bigger than that of second-degree relatives and third-degree relatives.
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Li et al. (2019) conducted a case-control in Essential hypertension (n=684). First-degree relative with essential hypertension vs. First-degree relative without essential hypertension was evaluated on Prevalence of hypertension in first-degree relatives (p=<0.001). Essential hypertension showed significant familial aggregation, with a heritability of 49.51% in first-degree relatives and a significantly higher prevalence among first-degree relatives of cases compared to controls (42.64% vs 26.43%).
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