Key result
Positive family history of hypertension is linked to ~6-year earlier onset of essential hypertension.
Why the study?
Genetic factors influence essential hypertension with family history serving as an important marker, but its association with onset age in the Han population in Shanghai required exploration.
Does a positive family history of hypertension associate with an earlier onset age of essential hypertension in the Han population?
Case-Control (n=684)
Yes
Does a positive family history of hypertension associate with an earlier onset age of essential hypertension in the Han population?
Absolute Event Rate: 48.74% vs 54.38%
p-value: p=<0.001
A positive family history of hypertension is significantly associated with an earlier age of onset of essential hypertension in the Han population in Shanghai.
Supports earlier screening in family-history patients; hypothesis-generating and requires prospective validation before practice change.
Importance Genetic factors are important influencing factors of essential hypertension, and family history (FH) is an important marker of genetic factors. Objective To explore the association between family history and the onset age of essential hypertension in Han population in Shanghai China. Methods According to l:l matched pairs design，342 precursor of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The diagnostic information of hypertension in all relatives of these two groups was investigated. The method of genetic epidemiology research was used to explore the effect of family history. Results The average prevalence of hypertension was 23.32%. The prevalence of hypertension of first-degree relatives was 33.99%; the prevalence of second- degree relatives was 17.60%; the prevalence of third-degree relatives was 13.51%. All prevalence of hypertension of case group relatives were significantly higher than that of control group relatives. The average onset age in population with positive FH is 48.74±11.16 years old, and the average onset age in population with negative FH is 54.38±9.87 years old. The difference about two FH groups showed statistically significant (t=4.589, P<0.001). The average onset age of offspring with father, mother, grandpa, grandma, maternal grandpa or maternal grandma positive was respectively 48.42± 11.16, 49.16±11.12, 39.55±11.95, 39.88±11.90, 43.67±9.77 or 43.64±10.21 years old; and the average onset age of children with father, mother, grandpa, grandma, maternal grandpa or maternal grandma negative was respectively 51.90± 10.81, 51.17±11.04, 51.07±10.59, 51.08±10.60, 50.50±11.09 or 50.57±11.06 years old. The difference about two groups showed statistically significant. Conclusion Family history has a positive effect on the occurrence of hypertension, and lead to earlier age of onset of offspring. The effects are different among parent and grandparent in Han in Shanghai China.
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Li et al. (2019) conducted a case-control in Essential hypertension (n=684). Positive family history of hypertension vs. Negative family history of hypertension was evaluated on Average onset age of hypertension (p=<0.001). A positive family history of hypertension was associated with a significantly earlier average onset age of essential hypertension (48.74 years) compared to a negative family history (54.38 years).
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