Key result
A positive family history of hypertension was associated with a significantly earlier onset age of essential hypertension compared to a negative family history (48.74 vs 54.38 years; P<0.001).
Why the study?
Genetic factors influence essential hypertension with family history serving as an important marker, but its association with onset age in the Han population in Shanghai required exploration.
Does a positive family history of hypertension reduce the onset age of essential hypertension in the Han population in Shanghai, China?
Case-Control (n=684)
Does a positive family history of hypertension reduce the onset age of essential hypertension in the Han population in Shanghai, China?
Absolute Event Rate: 48.74% vs 54.38%
p-value: p=<0.001
A positive family history of hypertension is associated with a significantly earlier age of onset of essential hypertension in the Han population in Shanghai, China.
May prompt earlier BP monitoring with positive family history; leaves open prospective validation and clinical impact.
Genetic factor is one of important influencing factors of essential hypertension, and family history (FH) is an important marker of genetic factors. To explore the association between family history and the onset age of essential hypertension in Han population in Shanghai China. According to l:l matched pairs design, 342 cases of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The diagnostic information of hypertension in all relatives of these two groups was investigated. The method of genetic epidemiology research was used to explore the effect of family history. The average prevalence of hypertension was 23.32%. The prevalence of hypertension of first-degree relatives was 33.99%; the prevalence of second- degree relatives was 17.60%; the prevalence of third-degree relatives was 13.51%. All prevalence of hypertension of case group relatives were significantly higher than that of control group relatives. The average onset age in population with positive FH is 48.74±11.16 years old, and the average onset age in population with negative FH is 54.38±9.87 years old. The difference about two FH groups showed statistically significant (t=4.589, P<0.001). The average onset age of offspring with father, mother, grandpa, grandma, maternal grandpa or maternal grandma positive was respectively 48.42± 11.16, 49.16±11.12, 39.55±11.95, 39.88±11.90, 43.67±9.77 or 43.64±10.21 years old; and the average onset age of children with father, mother, grandpa, grandma, maternal grandpa or maternal grandma negative was respectively 51.90± 10.81, 51.17±11.04, 51.07±10.59, 51.08±10.60, 50.50±11.09 or 50.57±11.06 years old. The difference about two groups showed statistically significant. Family history has a positive effect on the occurrence of hypertension, and lead to earlier age of onset of offspring. The effects are different among parent and grandparent in Han in Shanghai China.
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Li et al. (2019) conducted a case-control in Essential hypertension (n=684). Positive family history of hypertension vs. Negative family history of hypertension was evaluated on Onset age of essential hypertension (p=<0.001). A positive family history of hypertension was associated with a significantly earlier onset age of essential hypertension compared to a negative family history (48.74 vs 54.38 years; P<0.001).
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