Key result
Family history of hypertension is linked to ~73% higher risk of developing hypertension.
Why the study?
The risk of family history of hypertension for new-onset hypertension may have been underestimated by excluding early-onset cases in previous studies.
Does a family history of hypertension increase the risk of developing hypertension more strongly than previously estimated when early-onset cases are included in the analysis?
Cohort (n=34,792)
Does a family history of hypertension increase the risk of developing hypertension more strongly than previously estimated when early-onset cases are included in the analysis?
Hazard Ratio: 1.73 (95% CI 1.67–1.79)
p-value: p=<0.001
The risk of developing hypertension associated with a family history is significantly higher than previously estimated when early-onset cases are properly accounted for in statistical models.
A family history (FH) of hypertension is associated with an increased risk of new-onset hypertension. However, the risk of FH estimated in normotensives using conventional methods may have been somewhat underestimated by excluding early-onset cases, who are highly likely to have FH of hypertension. This large-scale longitudinal study on a middle-aged population (mean age: 46.8 years) revealed that the hazard ratio of FH of hypertension for the development of hypertension was higher when calculated for the entire study population (N = 34,792), including hypertensives at baseline by treating them as left-censored cases, using an interval-censored Cox proportional hazards model (1.73, 95% confidence interval: 1.67-1.79, P < 0.001) than that calculated in normotensives (n = 28,271) using a conventional Cox model (1.35, 95% confidence interval: 1.28-1.44, P < 0.001). The effect of changes in the possible confounders during the follow-up period was negligible. Thus, the risk of FH of hypertension for the development of hypertension may be higher than previously reported.
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Tabara et al. (2026) conducted a cohort in Hypertension (n=34,792). Family history of hypertension vs. No family history of hypertension was evaluated on Development of hypertension (HR 1.73, 95% CI 1.67-1.79, p=<0.001). A family history of hypertension was strongly associated with the development of hypertension when calculating risk for the entire cohort including baseline hypertensives (HR 1.73; 95% CI 1.67-1.79; P<0.001).
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