Key result
The nitrous oxide method established that the mean cerebral blood flow in normal young men is 54 cc/100 g/min and mean cerebral oxygen consumption is 3.3 cc O2/100 g/min.
Observational (n=14)
No
Describes the theory, procedure, and normal values for the nitrous oxide method to quantify cerebral blood flow in humans.
Establishes foundational normal values for cerebral perfusion and metabolism; leaves open validation in disease with modern methods.
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Kety et al. (1948) conducted an observational in Healthy (n=14). Nitrous oxide method (15% N2O inhalation) was evaluated on Mean cerebral blood flow (cc/100 g/min). The nitrous oxide method established that the mean cerebral blood flow in normal young men is 54 cc/100 g/min and mean cerebral oxygen consumption is 3.3 cc O2/100 g/min.
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