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January 1, 1951CirculationOpen Access

A Comparison of Coronary Flow Determined by the Nitrous Oxide Method and by a Direct Method Using the Rotameter

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Key result

The nitrous oxide method provided semiquantitative coronary flow values in dogs, with an average variation of ±12.4% compared to direct measurement using a rotameter.

Authors

DGDonald E. GreggWalter Reed Army Institute of ResearchFLFrank H. LonginoUnited States Department of the ArmyPGPaul GreenMichigan Department of Transportation

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Implication

Validates experimental coronary flow assessment in dogs; leaves open human validation and clinical utility.

Key Points

  • This research investigates the accuracy of the nitrous oxide method versus the rotameter direct method for measuring coronary flow in dogs.
  • Used nitrous oxide procedure for measuring coronary flow in dogs.
  • Compared with rotameter for inflow measurement in the left coronary artery.
  • Controlled for epicardial leak with appropriate heart covering.
  • Coronary flow measurement varied from +21% to -22%.
  • Average variation from nitrous oxide method was ±12.4%.
  • Nitrous oxide method provides semiquantitative coronary flow values.

PICO

P
Population
Coronary flow measurement
I
Intervention / Comparator
Nitrous oxide method vs Direct method using the rotameter
O
Primary Outcome
Coronary flow per minute per 100 Gm. of heart

Limitations

  • Potential error arising from epicardial leak of nitrous oxide

Cite This Study

Gregg et al. (1951) studied Coronary flow measurement. Nitrous oxide method vs. Direct method using the rotameter was evaluated on Coronary flow per minute per 100 Gm. of heart. The nitrous oxide method provided semiquantitative coronary flow values in dogs, with an average variation of ±12.4% compared to direct measurement using a rotameter.

synapsesocial.com/papers/6a0cfb6632f3c40b5ccbb025https://doi.org/10.1161/01.cir.3.1.89
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES 11948 · 2,077 citations
  2. 2DYNAMIC ANATOMY OF THE CEREBRAL CIRCULATION1948 · 249 citations