Key result
Hypophysectomy lowers and gonadotropin raises testicular renin in rats, demonstrating gonadotropin-dependent renin in Leydig cells.
Population
Rats (testes model)
Design
Preclinical
Authors
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Identifies gonadotropin-regulated testicular renin in rats; leaves open its role in human reproduction or disease.
This study demonstrates the presence of gonadotropin-dependent renin in rat Leydig cells, indicating independent control of testicular and plasma renin levels.
Naruse et al. (1984) studied this question. Hypophysectomy and gonadotropin treatment was evaluated on Testicular renin levels. Hypophysectomy significantly decreased testicular renin levels, whereas gonadotropin treatment remarkably increased them, indicating the presence of gonadotropin-dependent renin in rat Leydig cells.
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