Key result
RAA myocytes in RHD show longer action potentials and distinct ion currents versus AS cells.
Why the study?
Do myocytes from the right atrial appendage and atrial septum of patients with rheumatic heart disease have distinct electrophysiological properties?
Do myocytes from the right atrial appendage and atrial septum of patients with rheumatic heart disease have distinct electrophysiological properties?
Myocytes from the right atrial appendage and atrial septum possess distinct electrophysiological properties, providing a mechanistic explanation for the differing efficacies of atrial pacing in these regions for treating atrial fibrillation.
No takes yet. Share an insight, caveat, or question.
Regional myocyte differences may explain variable AF pacing efficacy; hypothesis-generating and should not yet change practice.
Gong et al. (2008) studied Rheumatic heart disease. Right atrial appendage (RAA) myocytes vs. Atrial septal (AS) myocytes was evaluated on Electrophysiological properties (action potential, ion currents). Right atrial appendage myocytes from patients with rheumatic heart disease exhibited longer action potential duration, more negative resting potential, and distinct ion current profiles compared to atrial septal myocytes.
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