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November 7, 2017Medicine & Science in Sports & Exercise

Workplace Strategies to Prevent Sitting-induced Endothelial Dysfunction

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Key result

Intermittent standing (post-FMD 1.9%) or desk pedaling (1.9%) did not prevent sitting-induced popliteal artery endothelial dysfunction compared to uninterrupted sitting (1.6%).

Why the study?

Does intermittent standing or desk pedaling prevent sitting-induced popliteal artery endothelial dysfunction in middle-age sedentary, overweight/obese office workers?

Population

13 middle-age, sedentary overweight/obese office workers

Comparison

4 hours of sitting interrupted with four… vs 4 hours of uninterrupted sitting

Design

RCT, randomized order

Follow-up

4 hours

Authors

NKNicholas T. KruseWHWilliam E. HughesRBRoberto M. Benzo

Discussion

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Overview

May not support brief standing or pedaling breaks to avert sitting-induced popliteal endothelial dysfunction; leaves open optimal interruption strategies for vascular protection.

Study Design

Type

RCT (n=13)

Randomization

Randomized order

Structured PICO

Does intermittent standing or desk pedaling prevent sitting-induced popliteal artery endothelial dysfunction in middle-age sedentary, overweight/obese office workers?

P
Population
13 middle-age, sedentary overweight/obese office workers (mean age 38 years) participating in three 4-hour testing sessions.
I
Intervention
4 hours of sitting interrupted with four 10-minute bouts of standing, or 4 hours of sitting interrupted with four 10-minute bouts of light-intensity desk pedaling
C
Comparator
4 hours of uninterrupted sitting
O
Outcome
Popliteal artery flow-mediated dilation measured by Doppler ultrasound immediately before and after each 4-hour interventionsurrogate

Main Result

Absolute Event Rate: 1.9% vs 1.6%

p-value: p=<0.05

Brief intermittent bouts of standing or desk pedaling are ineffective at preventing sitting-induced leg endothelial dysfunction in middle-aged sedentary overweight/obese adults.

Cite This Study

Kruse et al. (2017) conducted an RCT in Sedentary, overweight/obese office workers (n=13). Intermittent standing or underdesk pedaling vs. Uninterrupted sitting was evaluated on Popliteal artery flow-mediated dilation (p=<0.05). Intermittent standing (post-FMD 1.9%) or desk pedaling (1.9%) did not prevent sitting-induced popliteal artery endothelial dysfunction compared to uninterrupted sitting (1.6%).

synapsesocial.com/papers/6aa26cbe74fc654bd03231aahttps://doi.org/10.1249/mss.0000000000001484
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