Key result
Local absence of tenomodulin in the chordae tendineae cordis is associated with abnormal vessel formation, matrix metalloproteinase activation, and tissue rupture.
The local loss of tenomodulin, an antiangiogenic factor, leads to angiogenesis and matrix metalloproteinase activation, which are associated with the rupture of chordae tendineae cordis.
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Tenomodulin loss may drive chordal rupture via angiogenesis in models; leaves open human relevance and therapeutic targeting.
Kimura et al. (2008) studied Rupture of the chordae tendineae cordis (n=28). Local absence of tenomodulin vs. Normal tenomodulin expression was evaluated on Angiogenesis, vascular endothelial growth factor-A expression, matrix metalloproteinase expression, and inflammatory cell infiltration. Local absence of tenomodulin in the chordae tendineae cordis is associated with abnormal vessel formation, matrix metalloproteinase activation, and tissue rupture.
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