Key result
Calcium antagonists were significantly more effective than other drugs in treating variant angina (87.1% vs 56.3% efficacy, p<0.05), and also demonstrated high efficacy in resting and unstable angina.
Why the study?
Do calcium antagonists (nifedipine) improve clinical response in patients with variant, resting, and unstable angina compared to other drugs?
Observational (n=150)
No
Do calcium antagonists (nifedipine) improve clinical response in patients with variant, resting, and unstable angina compared to other drugs?
Absolute Event Rate: 87.1% vs 56.3%
p-value: p=<0.05
Calcium antagonists, particularly nifedipine, demonstrate significant clinical effectiveness in the management of variant, resting, and unstable angina.
May support calcium antagonists for variant angina; leaves open randomized confirmation versus contemporary regimens.
The effects of drugs were evaluated in 47 cases with variant angina (VA), 19 with resting angina showing ST depression (RA), and 84 with unstable angina (UA). In VA patients, calcium antagonists were effective in 87.1% of the cases, while other drugs were effective in 56.3%. The difference was statistically significant. In RA patients, calcium antagonists were effective in 80.0% of the cases and other drugs in 44.4%. Nifedipine was effective in all 5 cases with coronary stenosis of more than 75.0%. All cases of RA had multiple vessel disease and nifedipine was effective in 80.0% of the patients. Nifedipine was effective in 83.3% of VA cases showing ST elevation during an exercise test, and was particularly effective in all patients having attacks only at rest. The effects of nifedipine were confirmed in 83.3% of UA cases. These results indicate that calcium antagonists are effective in VA, RA, and UA.
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Kishida et al. (1982) conducted an observational in Variant, resting, and unstable angina (n=150). Calcium antagonists (Nifedipine) vs. Other antianginal drugs (isosorbide, propranolol, etc.) was evaluated on Effectiveness (complete elimination or ≥50% reduction of anginal attacks) in variant angina (p=<0.05). Calcium antagonists were significantly more effective than other drugs in treating variant angina (87.1% vs 56.3% efficacy, p<0.05), and also demonstrated high efficacy in resting and unstable angina.
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