Key result
Tamoxifen prolongs action potential duration and reduces key potassium currents by ~21% in rat myocytes.
Why the study?
Does tamoxifen alter action potential waveforms and ion currents in rat ventricular myocytes?
Does tamoxifen alter action potential waveforms and ion currents in rat ventricular myocytes?
Tamoxifen inhibits multiple potassium and sodium currents in rat ventricular myocytes, providing a mechanistic explanation for its QT-prolonging and arrhythmogenic effects.
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Raises caution for tamoxifen-related QT effects in patients; leaves open translation of rat myocyte findings to human arrhythmogenesis.
He et al. (2003) studied this question. Tamoxifen vs. pretreatment values was evaluated on Cardiac action potential waveforms and underlying K+ and Na+ currents. Tamoxifen prolonged action potential duration and significantly depressed Ito, Isus, IK1 (to 79% of pretreatment values at 1 micromol/l), and INa in rat ventricular myocytes.
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