Key result
Hexapolar multielectrode catheter ablation yields inferior LA linear block rates versus conventional ablation.
Why the study?
Does a hexapolar linear multielectrode ablation catheter effectively create left atrial linear block in patients with atrial fibrillation?
Observational (n=17)
Does a hexapolar linear multielectrode ablation catheter effectively create left atrial linear block in patients with atrial fibrillation?
A novel hexapolar linear multielectrode catheter using duty-cycled bipolar and unipolar RF energy demonstrated limited efficacy in achieving left atrial linear block compared to conventional methods.
Hexapolar multielectrode catheter should not yet replace conventional ablation for left atrial lines; hypothesis-generating for future catheter optimization in AF.
INTRODUCTION: Creating complete linear block with point-by-point ablation is challenging in the left atrium (LA). The purpose of this study was to evaluate the efficacy of LA linear ablation using a hexapolar linear multielectrode mapping/ablation catheter. METHODS AND RESULTS: Seventeen patients (age 57 ± 10, 14 male, 6 paroxysmal AF (PAF)) were studied and underwent linear ablation at the mitral isthmus (MI) and LA roof. Ablation was performed with 90 second, 60 °C applications of duty-cycled bipolar/unipolar radiofrequency in a 1:1 ratio simultaneously at all selected electrode pairs. The result could not be evaluated in 2 patients because AF persisted despite cardioversion. Roof line block was confirmed in 9 of 15 (60%) patients. The mean number of applications and the procedural time with and without block was 5.4 ± 2.4 and 4.5 ± 2.2 applications, and 15 ± 8 and 13 ± 7 minutes. MI block was confirmed in 4 of 15 (27%) patients. The mean number of RF applications with and without block was 5.3 ± 2.2 and 9.9 ± 4.4 applications, and the procedural time was 20 ± 9 and 27 ± 10 minutes, respectively. For patients with underlying persistent AF, power was lower than those with PAF but improved when ablation was performed in sinus rhythm. Char was observed in 2 cases; however, no procedure-related complications were observed. CONCLUSIONS: In our initial experience, a linear multielectrode catheter using duty-cycled bipolar and unipolar RF energy was inferior to conventional single point irrigated ablation in achieving LA linear block. However, successful linear block was obtained within a short period of time, when it was achieved.
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Miyazaki et al. (2011) conducted an observational in Atrial fibrillation (n=17). Hexapolar linear multielectrode mapping/ablation catheter was evaluated on Left atrial linear block (roof line and mitral isthmus). Left atrial linear ablation using a hexapolar multielectrode catheter achieved roof line block in 60% and mitral isthmus block in 27% of patients, which was considered inferior to conventional ablation.
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