Key result
LAAC with Sentinel CPS achieves 100% procedural success without stroke or TIA for persistent LAA thrombus.
Why the study?
Presence of thrombus in the left atrial appendage is a contraindication to percutaneous closure due to embolic risk, prompting evaluation of the Sentinel cerebral protection system to support the procedure.
Does the Sentinel cerebral protection system safely support left atrial appendage closure in patients with non-valvular atrial fibrillation and persistent LAA thrombus?
Observational (n=27)
Yes
Does the Sentinel cerebral protection system safely support left atrial appendage closure in patients with non-valvular atrial fibrillation and persistent LAA thrombus?
The use of the Sentinel cerebral protection system during left atrial appendage closure in patients with persistent LAA thrombus appears safe and technically feasible, potentially overcoming a traditional contraindication.
Authors
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Supports Sentinel CPS-assisted LAA closure in persistent thrombus; hypothesis-generating and should not yet change practice.
Boccuzzi et al. (2020) conducted an observational in Non-valvular atrial fibrillation with persistent LAA thrombus (n=27). Left atrial appendage closure (LAAC) supported by Sentinel cerebral protection system (CPS) was evaluated on Technical and procedural success. Left atrial appendage closure supported by Sentinel CPS achieved 100% technical and procedural success with 0% periprocedural stroke or TIA in patients with persistent LAA thrombus.
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