Key result
Concomitant simvastatin and fluconazole linked to severe rhabdomyolysis that resolves upon discontinuation.
Why the study?
Does concomitant use of simvastatin and fluconazole cause rhabdomyolysis?
Case Report (n=1)
No
Does concomitant use of simvastatin and fluconazole cause rhabdomyolysis?
Concomitant use of simvastatin and fluconazole can cause rhabdomyolysis due to CYP450 inhibition, highlighting the need for vigilance regarding drug interactions with statins.
No takes yet. Share an insight, caveat, or question.
Alerts clinicians to possible simvastatin-fluconazole interaction in elderly patients; single case report leaves open population risk assessment.
Shaukat et al. (2003) conducted a case report in Rhabdomyolysis (n=1). Simvastatin and fluconazole was evaluated on Rhabdomyolysis. Concomitant use of simvastatin and fluconazole caused severe rhabdomyolysis in an 83-year-old man, which resolved following discontinuation of both drugs.
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