Key result
Oral FAdV-11 infection causes severe hepatic necrosis and reduced weight gain in chickens.
Why the study?
Outbreaks of inclusion body hepatitis emerged in Morocco, but the pathogenicity of the characterized fowl adenovirus isolates had never been investigated.
Comparison
Oral inoculation with FAdV 11 (MOR300315 strain) vs injection with phosphate-buffered saline solution
Design
Experimental infection study
Authors
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Confirms FAdV-11 pathogenicity in young SPF chickens; leaves open field validation and preventive strategies in commercial poultry.
p-value: p=<0.05
The FAdV 11 strain isolated in Morocco is pathogenic in chickens, causing inclusion body hepatitis and decreased weight gain, highlighting the need for preventive measures.
Abghour et al. (2021) studied Inclusion body hepatitis (n=80). Fowl aviadenovirus serotype 11 (MOR300315 strain) vs. Phosphate-buffered saline (PBS) was evaluated on Pathogenicity (weight gain, gross and microscopic lesions, viral shedding) (p=<0.05). Experimental oral infection of 3-day-old SPF chickens with FAdV-11 strain MOR300315 caused significant weight gain reduction, severe hepatic necrosis, and viral shedding, confirming its pathogenicity.
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