Key result
Fixed-dose combination antihypertensives are recommended for most patients to achieve target BP and improve adherence.
Management of hypertension often requires combination therapy, and fixed-dose combinations are recommended to improve treatment adherence and achieve target blood pressure.
Combination therapy may enhance BP control in resistant hypertension; leaves open optimal first-line regimens pending randomized data.
Hypertension is an extremely common condition and quantitatively the most important risk factor for cardiovascular disease and mortality. Cardiovascular risk factors other than hypertension occur more frequently in hypertensive subjects and contribute to the elevated cardiovascular risk. Management of hypertensive subjects includes lifestyle modification and, usually, treatment with antihypertensive agents. Due to the limited blood pressure lowering effect of a single antihypertensive agent, more than 2/3 of hypertensive patients require at least two or more antihypertensive agents to achieve target blood pressure. For combination therapy combining an agent that interferes with the renin-angiotensin system with an agent that does not is recommended. Treatment adherence and persistence can be improved by using fixed-dose combinations instead of single agents.
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Anton H. van den Meiracker (2013) conducted a review in Hypertension. Fixed-dose combination antihypertensive therapy vs. Single antihypertensive agents was evaluated. Fixed-dose combination antihypertensive therapy is recommended for the majority of hypertensive patients to achieve target blood pressure and improve treatment adherence.
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