Key result
Beta-blockers and diuretics are associated with reduced urinary calcium excretion, and beta-blockers with higher ionized calcium.
Why the study?
Does antihypertensive monotherapy improve indices of systemic mineral metabolism in hypertensive patients?
Population
319 hypertensive patients
Design
Cohort
Follow-up
3 to 6 months
Authors
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Associations with calcium handling should not change prescribing; hypothesis-generating for sympathetic-mineral links and requires randomized trials.
Observational (n=319)
Does antihypertensive monotherapy improve indices of systemic mineral metabolism in hypertensive patients?
p-value: p=<.001
Beta-blockers appear to reverse the basic abnormality in calcium balance seen in hypertensive patients, suggesting sympathetic nervous system involvement.
Li-na et al. (1994) conducted an observational in hypertension (n=319). Antihypertensive monotherapy was evaluated on serum and fasting urinary electrolytes (p=<.001). Beta-blockers and diuretics reduced fasting urinary calcium excretion (P<0.001), while beta-blockers increased the proportion of ionized calcium in blood (P<0.001).