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March 1, 1993Endocrinology

Insulin-like growth factor binding protein-3 is present in the alpha-granules of platelets.

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Key result

Human platelet alpha-granules contain IGFBP-3 alongside IGFs to potentially regulate their actions upon release.

Population

Isolated human platelets

Design

Preclinical

Authors

ESEugenio SpencerATA TokunagaTHT K Hunt

Discussion

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Overview

May modulate IGF bioavailability in platelet-rich thrombi; leaves open its role in vascular disease.

Structured PICO

P
Population
Isolated human platelets
E
Exposure
Thrombin digestion to release alpha-granule contents
O
Outcome
Presence of IGFBP-3 in the alpha-granule lysatesurrogate

The study demonstrates that IGFBP-3 is present in human platelet alpha-granules, where it may regulate the actions of released IGFs.

Cite This Study

Spencer et al. (1993) studied this question. Thrombin digestion of human platelets was evaluated on Presence of IGFBP-3 in platelet alpha-granules. IGFBP-3 is present in the alpha-granules of human platelets, coexisting with IGFs and potentially regulating their actions upon release by lysis.

synapsesocial.com/papers/6aa2d729331da8fac1a57fc3https://doi.org/10.1210/endo.132.3.7679986
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IGFBP-3 proteolysis by plasmin, thrombin, serum: heparin binding, IGF binding, and structure of fragments1996 · 65 citations
  2. 2Identification of Novel High Molecular Weight Insulin-Like Growth Factor-Binding Protein-3 Association Proteins in Human Serum11998 · 12 citations
  3. 3Platelet alpha granules contain a growth factor for fibroblasts1979 · 356 citations
  4. 4IGFBP-3 binding to endothelial cells inhibits plasmin and thrombin proteolysis2002 · 14 citations
  5. 5Regulation of insulin‐like growth factor (IGF) binding protein‐2 synthesis and degradation by platelet‐derived growth factor and the IGFs is enhanced by serum deprivation in vascular smooth muscle cells1995 · 32 citations