Key result
Adding nifedipine to chronic digoxin in AF increases serum digoxin levels by ~15%.
Why the study?
Does adding nifedipine alter serum digoxin concentrations and hemodynamics in patients with atrial fibrillation receiving chronic digoxin?
Population
9 patients with atrial fibrillation who were receiving chronic digoxin
Comparison
Nifedipine in a sustained release formulation… vs 2 control weeks on chronic digoxin alone prior…
Design
Cohort
Follow-up
4 weeks (2 control weeks, 2 intervention weeks)
Authors
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May support vigilance for digoxin interactions with nifedipine in AF; small cohort study leaves open need for monitoring protocols.
Does adding nifedipine alter serum digoxin concentrations and hemodynamics in patients with atrial fibrillation receiving chronic digoxin?
Effect estimate: 15% increase
Absolute Event Rate: 1.04% vs 0.87%
p-value: p=<0.05
Adding nifedipine to chronic digoxin slightly elevates plasma digoxin levels, but this increase is likely of little clinical relevance.
Kleinbloesem et al. (1985) studied Atrial fibrillation (n=9). Nifedipine vs. Baseline (digoxin alone) was evaluated on Serum digoxin levels (15% increase, p=<0.05). Addition of nifedipine to chronic digoxin therapy in patients with atrial fibrillation increased serum digoxin levels by 15% (from 0.87 to 1.04 ng/ml; p<0.05).
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