Why the study?
Does nifedipine or diltiazem affect digoxin kinetics in patients with cardiac insufficiency?
Population
23 patients with cardiac insufficiency achieving steady-state conditions on digoxin
Comparison
Nifedipine (n=11) or diltiazem (n=12) vs Baseline (before dosing)
Design
Cohort
Follow-up
10 to 14 days (for nifedipine group)
Authors
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Diltiazem may increase digoxin levels; hypothesis-generating and requires randomized confirmation before practice change.
Does nifedipine or diltiazem affect digoxin kinetics in patients with cardiac insufficiency?
Diltiazem, but not nifedipine, significantly increases digoxin plasma concentrations, necessitating close monitoring and potential dose reduction to avoid toxicity.
J. Kuhlmann (1985) studied this question.
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