Key result
Oral nifedipine does not alter steady-state digoxin concentrations or renal clearance.
Why the study?
Does oral nifedipine alter serum digoxin concentration and renal digoxin clearance in healthy male subjects?
Population
20 healthy male subjects
Comparison
Digoxin 0.375 mg a day with oral nifedipine 18.5… vs Digoxin 0.375 mg a day with placebo for 2 weeks
Design
Other
Follow-up
6 weeks (2 weeks per phase)
Authors
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Nifedipine coadministration appears safe regarding digoxin levels in healthy men; leaves open effects in patients with heart failure or reduced clearance.
Does oral nifedipine alter serum digoxin concentration and renal digoxin clearance in healthy male subjects?
Absolute Event Rate: 0.77% vs 0.74%
Oral nifedipine does not significantly alter serum digoxin concentrations or decrease renal digoxin clearance in healthy subjects.
Schwartz et al. (1984) studied Healthy (n=20). Oral nifedipine vs. Placebo was evaluated on Steady-state digoxin concentrations. Oral nifedipine did not alter steady-state digoxin concentrations (0.77 ng/ml vs 0.74 and 0.75 ng/ml on placebo) or decrease renal clearance in healthy male subjects.
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