Why the study?
Does diltiazem alter the pharmacokinetics of digoxin in healthy subjects?
Population
6 healthy subjects
Comparison
Diltiazem 30 mg three times daily for 1 week… vs Single oral dose of digoxin without diltiazem
Design
Other
Authors
Loading...
Alerts to potential digoxin accumulation with diltiazem; extends PK data but leaves open outcome implications in patients.
Does diltiazem alter the pharmacokinetics of digoxin in healthy subjects?
Diltiazem interacts with digoxin by reducing its renal clearance and increasing plasma concentrations, highlighting a pharmacokinetic drug-drug interaction.
Yoshida et al. (1984) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: