Key result
The percentage of unbound diltiazem in human serum ranged from 19.6% to 22.6%, was independent of concentration, and was not influenced by concurrent cardiac medications.
Why the study?
What is the serum binding of diltiazem in humans and is it affected by concentration or concurrent cardiac medications?
What is the serum binding of diltiazem in humans and is it affected by concentration or concurrent cardiac medications?
Diltiazem serum binding is constant across therapeutic concentrations and is not altered by common concurrent cardiac medications.
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Diltiazem binding stability may simplify free-drug predictions without co-medication adjustments; leaves open generalizability to broader populations.
Bloedow et al. (1982) studied Healthy (n=5). Diltiazem was evaluated on Percentage of unbound diltiazem. The percentage of unbound diltiazem in human serum ranged from 19.6% to 22.6%, was independent of concentration, and was not influenced by concurrent cardiac medications.