Key result
Nitric oxide plays a dual role in living cells, acting as an essential signaling molecule in physiological processes while also contributing to the pathogenesis of various diseases.
Why the study?
Nitric oxide is an essential signaling molecule with dual beneficial and harmful effects depending on its concentration and site of production, requiring objective discussion of its biochemical and physiological roles in health and disease.
This review highlights the dual functionality of nitric oxide in living cells, emphasizing its roles in cell signaling, oxidative stress, immunity, and cardiovascular protection.
Supports cautious nitric oxide modulation in cardiovascular disease; leaves open targeted interventions pending further studies.
Nitric Oxide (NO) is an essential signaling molecule with diverse physiological functions in humans. The steady-state concentration and site of production of nitric oxide determine its effects in biological systems. The human cells are exposed to both beneficial and harmful effects of NO. These dual effects of NO could depend on its local concentration in the cells. Additionally, the rate of synthesis, translocation, direct interaction with other molecules, and signals contribute to the biochemical and physiological effects of NO. In this review, the biochemical and physiological role of NO, particularly in health and disease as touching on cell signaling, oxidative stress, immunity, as well as cardiovascular protection amongst others, is focused on. Therefore, this review objectively discusses the dual functionality of NO in living cells.
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Akanji et al. (2020) conducted a review in Various diseases. Nitric oxide was evaluated. Nitric oxide plays a dual role in living cells, acting as an essential signaling molecule in physiological processes while also contributing to the pathogenesis of various diseases.
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