Key result
Recent Berlin Heart EXCOR support linked to ~27% higher survival in children <5 kg.
Why the study?
Does recent era management improve overall survival in low-weight children (<10 kg) supported with the Berlin Heart EXCOR ventricular assist device compared to an earlier era?
Population
1,832 children supported with the Berlin Heart EXCOR ventricular assist device, stratified by weight
Comparison
Berlin Heart EXCOR ventricular assist device… vs Berlin Heart EXCOR ventricular assist device…
Design
Cohort
Authors
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Recent-era survival gains in <5 kg infants on EXCOR support cautious VAD consideration; leaves open optimal selection and prospective validation.
Cohort (n=1,832)
Does recent era management improve overall survival in low-weight children (<10 kg) supported with the Berlin Heart EXCOR ventricular assist device compared to an earlier era?
Absolute Event Rate: 65% vs 51%
p-value: p=<0.001
Survival of low-weight children (<10 kg) supported with the Berlin Heart EXCOR ventricular assist device has significantly improved in recent years, suggesting body weight alone should not preclude VAD therapy.
Miera et al. (2018) conducted a cohort in Paediatric heart failure requiring ventricular assist device support (n=1,832). Implantation in Era 2 (January 2013-June 2017) vs. Implantation in Era 1 (January 2000-December 2012) was evaluated on Overall survival in children weighing <5 kg (p=<0.001). Overall survival for children weighing <5 kg supported by the Berlin Heart EXCOR ventricular assist device significantly improved from 51% in 2000-2012 to 65% in 2013-2017 (P<0.001).
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