Key result
Loss of alleles on chromosomes 11p (4 of 6 patients), 13q (3 of 6), and 17p (all heterozygous patients) occurred in adrenocortical carcinomas but not in benign adrenal lesions.
Population
17 patients (9 with adrenocortical carcinomas and 8 with benign adrenal cortical lesions)
Design
Other
Authors
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Allelic losses may distinguish adrenocortical carcinomas from benign lesions; hypothesis-generating and should not yet change practice.
Observational (n=17)
Consistent genetic changes involving loss of alleles on chromosomes 11p, 13q, and 17p are implicated in the pathogenesis of adrenocortical carcinoma.
Yano et al. (1989) conducted an observational in Adrenocortical carcinomas and benign adrenal cortical lesions (n=17). Adrenocortical carcinoma vs. Benign adrenal cortical lesions was evaluated on Loss of alleles at loci on human chromosomes 11, 13, and 17. Loss of alleles on chromosomes 11p (4 of 6 patients), 13q (3 of 6), and 17p (all heterozygous patients) occurred in adrenocortical carcinomas but not in benign adrenal lesions.
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