Key result
Protein-creatinine ratio and albumin-creatinine ratio had small mean differences (0.03 g/day and 0.10 g/day) vs 24h urine protein, but agreement fell substantially above 1.5 g/day.
Why the study?
Are protein-creatinine ratio and albumin-creatinine ratio comparable to 24h urine protein for monitoring proteinuria in clinical trials?
Population
27 patients with proteinuric chronic kidney disease
Comparison
Protein-creatinine ratio and albumin-creatinine… vs 24h urine protein measurement
Design
Cohort
Authors
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PCR/ACR may substitute for 24h urine protein below 1.5 g/day; leaves open reliability for higher-proteinuria monitoring in trials.
Observational (n=27)
Are protein-creatinine ratio and albumin-creatinine ratio comparable to 24h urine protein for monitoring proteinuria in clinical trials?
Effect estimate: Mean difference 0.03 g/day (PCR) and 0.10 g/day (ACR)
p-value: p=0.63 (PCR), 0.38 (ACR)
PCR and ACR show similar accuracy and repeatability to 24h urine protein for monitoring proteinuria, though agreement decreases at higher proteinuria levels.
Towler et al. (2012) conducted an observational in Proteinuric chronic kidney disease (n=27). Protein-creatinine ratio (PCR) and albumin-creatinine ratio (ACR) vs. 24h urine protein was evaluated on Agreement and repeatability compared to 24h urine protein (Mean difference 0.03 g/day (PCR) and 0.10 g/day (ACR), p=0.63 (PCR), 0.38 (ACR)). Protein-creatinine ratio and albumin-creatinine ratio had small mean differences (0.03 g/day and 0.10 g/day) vs 24h urine protein, but agreement fell substantially above 1.5 g/day.
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