Key result
Elevated plasma BNP (OR 14.3), abnormal heart rate turbulence (OR 13.6), and prior MVA or syncope (OR 11.1) were independent predictors of malignant ventricular arrhythmias in patients with CAD.
Why the study?
What are the independent noninvasive predictors of malignant ventricular arrhythmias in patients with stable coronary artery disease?
Population
97 patients with stable documented coronary artery disease, mean age 61 ± 10 years, 68% with heart failure…
Design
Cohort
Follow-up
mean 25 ± 11 months
Authors
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May aid noninvasive SCD risk stratification in stable CAD; hypothesis-generating pending prospective validation.
Cohort (n=97)
No
What are the independent noninvasive predictors of malignant ventricular arrhythmias in patients with stable coronary artery disease?
Odds Ratio: 14.3 (95% CI 3.2–65)
p-value: p=<0.01
Prior syncope or MVA, abnormal heart rate turbulence, and elevated plasma BNP independently predict malignant ventricular arrhythmias in patients with stable CAD, suggesting utility for sudden cardiac death risk stratification.
Голухова et al. (2016) conducted a cohort in Stable documented coronary artery disease (CAD) (n=97). Elevated plasma BNP, abnormal heart rate turbulence, and prior MVA/syncope vs. Absence of these risk factors was evaluated on Malignant ventricular arrhythmia (MVA) occurrence (OR 14.3, 95% CI 3.2-65.0, p=<0.01). Elevated plasma BNP (OR 14.3), abnormal heart rate turbulence (OR 13.6), and prior MVA or syncope (OR 11.1) were independent predictors of malignant ventricular arrhythmias in patients with CAD.
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