Key result
Cisapride 10 mg increases lower esophageal sphincter pressure ~40% vs placebo, without further 20 mg benefit.
Why the study?
Does cisapride improve esophageal motility in healthy male volunteers?
Population
10 healthy male volunteers
Comparison
Repeated oral doses of cisapride at 10 mg and 20… vs Placebo
Design
RCT, double-blind
Follow-up
60 min per experiment
Authors
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Supports 10 mg dosing for esophageal motility research; confirms efficacy plateau without added benefit at 20 mg in healthy volunteers.
RCT (n=10)
Double-blind
Does cisapride improve esophageal motility in healthy male volunteers?
Absolute Event Rate: 28.9% vs 20.6%
p-value: p=<0.0001
Cisapride at 10 mg significantly increases lower esophageal sphincter pressure and enhances esophageal contraction waves in healthy volunteers, with no additional benefit at 20 mg.
Katschinski et al. (2009) conducted an RCT in Healthy (n=10). Cisapride vs. Placebo was evaluated on Lower esophageal sphincter pressure (p=<0.0001). Cisapride at 10 mg significantly increased lower esophageal sphincter pressure compared to placebo (28.9 vs 20.6 mm Hg, p<0.0001), with no further enhancement at 20 mg.
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