August 1, 1987Journal of Gastroenterology and Hepatology
The effects of cisapride on gastric and oesophageal emptying in dystrophia myotonica
Why the study?
Does cisapride improve gastric and oesophageal emptying and gastrointestinal symptoms in patients with dystrophia myotonica?
Population
10 patients with dystrophia myotonica who had delayed gastric emptying of the solid and/or liquid component…
Comparison
Cisapride (10 mg, q.i.d., p.o.) for 4 weeks vs Baseline (before taking cisapride)
Design
Cohort
Follow-up
4 weeks
Authors
Discussion
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Implication
May support symptomatic management of gastroparesis in myotonic dystrophy; leaves open need for randomized confirmation.
Structured PICO
Does cisapride improve gastric and oesophageal emptying and gastrointestinal symptoms in patients with dystrophia myotonica?
P
Population
10 patients with dystrophia myotonica who had delayed gastric emptying of the solid and/or liquid component of a meal
I
Intervention
Cisapride (10 mg, q.i.d., p.o.) for 4 weeks
C
Comparator
Baseline (before taking cisapride)
O
Outcome
Gastric emptying, oesophageal emptying, and gastrointestinal symptomssurrogate
Cisapride improves solid gastric emptying and upper gastrointestinal symptoms in patients with dystrophia myotonica, suggesting gastroparesis is a treatable cause of morbidity in this population.
Cite This Study
Horowitz et al. (1987) studied this question.