Key result
Neither cisapride nor metoclopramide significantly improved oesophageal transit, gastric emptying, whole-gut transit, or symptoms compared to placebo in diabetic autonomic neuropathy.
Why the study?
Do oral cisapride and metoclopramide improve gastrointestinal transit and symptoms in diabetic patients with autonomic neuropathy?
Population
19 diabetic patients with autonomic neuropathy (16 analyzed)
Comparison
Oral cisapride and oral metoclopramide vs Placebo
Design
RCT, double-blind
Follow-up
8 weeks per treatment period
Authors
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Does not support cisapride or metoclopramide for GI symptoms in diabetic autonomic neuropathy; challenges prior assumptions of prokinetic efficacy.
RCT (n=19)
Double-blind
Do oral cisapride and metoclopramide improve gastrointestinal transit and symptoms in diabetic patients with autonomic neuropathy?
Oral cisapride and metoclopramide do not significantly improve objective gastrointestinal transit abnormalities or symptoms in patients with diabetic autonomic neuropathy.
Caestecker et al. (1989) conducted an RCT in Diabetic autonomic neuropathy (n=19). Cisapride and metoclopramide vs. Placebo was evaluated on Oesophageal transit, gastric emptying, whole gut transit, and symptoms. Neither cisapride nor metoclopramide significantly improved oesophageal transit, gastric emptying, whole-gut transit, or symptoms compared to placebo in diabetic autonomic neuropathy.
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