Key result
Canine IMA grafts to patent arteries maintain flow ~11% above baseline, suggesting competitive flow avoids shriveling.
Why the study?
Does competitive flow from a fully patent coronary artery limit acute mammary graft flow in a canine model?
Population
10 dogs (mean weight, 23.5 +/- 3.69 kg)
Comparison
Coronary artery bypass grafting using the… vs Transient occlusion of the CFX proximal to the…
Design
Preclinical
Follow-up
acute
Authors
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Questions competitive flow as driver of acute IMA shriveling; leaves open relevance to human CABG graft failure.
Does competitive flow from a fully patent coronary artery limit acute mammary graft flow in a canine model?
Absolute Event Rate: 26.5% vs 23.8%
In a canine model, acute competitive flow from a fully patent coronary artery does not limit IMA graft flow below in situ levels, suggesting it may not be the primary cause of acute mammary artery shriveling.
Spence et al. (1992) studied Coronary artery bypass grafting (experimental model) (n=10). IMA grafting to a fully patent coronary artery vs. In situ IMA flow / occluded proximal CFX was evaluated on IMA graft flow. In an acute canine model, IMA graft flow was maintained above in situ levels (26.5 vs 23.8 mL/min) when grafted to a fully patent coronary artery, suggesting competitive flow does not cause shriveling.
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