Key result
Atherosclerosis burden score ≥2 on duplex ultrasound predicts ~98% more cardiovascular events in asymptomatic T2D.
Why the study?
The study aimed to identify new independent vascular markers to predict cardiovascular events in patients with type-2 diabetes and evaluate their incremental value over the Swedish National Diabetes Register risk score.
Does Duplex ultrasonography to detect carotid and femoral plaque improve cardiovascular risk prediction compared to the NDR risk score in asymptomatic patients with type-2 diabetes?
Population
1332 asymptomatic patients with type-2 diabetes free from prior CV events
Comparison
Atherosclerosis burden score via carotid and femoral Duplex ultrasonography vs Swedish National Diabetes Register risk score
Design
Retrospective cohort study
Follow-up
Up to 5 years
Authors
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May support duplex ultrasonography for risk stratification in asymptomatic type-2 diabetes; leaves open prospective validation versus NDR score.
Cohort (n=1,332)
Does Duplex ultrasonography to detect carotid and femoral plaque improve cardiovascular risk prediction compared to the NDR risk score in asymptomatic patients with type-2 diabetes?
Hazard Ratio: 1.98 (95% CI 1.21–3.25)
p-value: p=0.007
Screening for carotid and femoral atherosclerotic plaques using Duplex ultrasonography significantly improves cardiovascular risk stratification beyond standard clinical risk scores in asymptomatic patients with type-2 diabetes.
Malaha et al. (2021) conducted a cohort in Type-2 diabetes (n=1,332). Atherosclerosis burden score (ABS) ≥ 2 vs. ABS < 2 was evaluated on Cardiovascular events (HR 1.98, 95% CI 1.21-3.25, p=0.007). An atherosclerosis burden score ≥ 2 on duplex ultrasonography independently predicted cardiovascular events in asymptomatic patients with type-2 diabetes (HR 1.98; 95% CI 1.21-3.25; p=0.007).
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