Key result
High blood pressure variability is linked to ~140% higher in-hospital MACE risk in ACS patients.
Why the study?
Does high blood pressure variability increase in-hospital major adverse cardiac events in patients with acute coronary syndrome?
Observational (n=200)
Does high blood pressure variability increase in-hospital major adverse cardiac events in patients with acute coronary syndrome?
Odds Ratio: 2.4 (95% CI 1.2–4.5)
Absolute Event Rate: 47% vs 27%
p-value: p=0.008
High short-term blood pressure variability is an independent predictor of in-hospital MACE in patients with acute coronary syndrome.
Identifies high BP variability as an ACS risk marker; leaves open whether targeting it improves in-hospital outcomes.
To evaluate the impact of blood pressure variability (BPV) on cardiovascular outcomes in patients with acute coronary syndrome, short-term BPV was estimated by using weighted standard deviation of 24-hour ambulatory blood pressure monitoring readings. The primary outcome was in-hospital major adverse cardiac events (MACE). Overall, 200 patients (mean age, 58.6 years; 27.5% women; 38% with diabetes mellitus; and 47% smokers) were divided into low and high BPV groups based on the median value (9.45). Patients in the high BPV group were more likely to have in-hospital MACE compared with patients with low BPV (47% vs 27%, P = .003). Multivariate binary logistic regression analysis of incidence of MACE showed that BPV (odds ratio, 2.4; confidence interval, 1.2-4.5 [P = .008]) and presence of type II diabetes mellitus (odds ratio, 2.6; confidence interval, 1.2-5.3 [P = .008]) were the only independent predictors of in-hospital MACE derived mainly by hypertensive emergencies. BPV could be an important risk factor for in-hospital MACE in patients with acute coronary syndrome.
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Hassan et al. (2017) conducted an observational in acute coronary syndrome (n=200). High blood pressure variability (BPV) vs. Low blood pressure variability (BPV) was evaluated on in-hospital major adverse cardiac events (MACE) (OR 2.4, 95% CI 1.2-4.5, p=0.008). High blood pressure variability was an independent predictor of in-hospital major adverse cardiac events in patients with acute coronary syndrome (OR 2.4; 95% CI 1.2-4.5; P=0.008).
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