Key result
Sympathetic cholinergic stimulation and acetylcholine alter skeletal muscle oxygen uptake predominantly via precapillary resistance vessels.
Population
Anesthetized dogs (skeletal muscle model)
Comparison
Activation of sympathetic cholinergic… vs Pre-stimulatory resting levels
Design
Preclinical
Authors
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Animal data distinguish cholinergic from adrenergic effects on muscle vessels; leaves open human translation and clinical relevance.
In dog skeletal muscle, sympathetic cholinergic stimulation and acetylcholine primarily dilate precapillary resistance vessels, whereas reflex inhibition of vasoconstrictor tone dilates both precapillary resistance vessels and precapillary sphincters.
Bolme et al. (1969) studied this question. Sympathetic cholinergic vasodilator nerve activation, reflex inhibition of vasoconstrictor tone, and acetylcholine infusion vs. Pre-stimulatory levels / resting values was evaluated on Oxygen uptake in skeletal muscle. Sympathetic cholinergic nervous stimulation and acetylcholine elicit changes in skeletal muscle oxygen uptake indicating an effect predominantly on precapillary resistance vessels.
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