Key result
Rigid amphipathic fusion inhibitors potently inhibit ASFV infection in vitro.
Why the study?
Do rigid amphipathic fusion inhibitors (aUY11 and cm1UY11) inhibit African swine fever virus infection in vitro?
Do rigid amphipathic fusion inhibitors (aUY11 and cm1UY11) inhibit African swine fever virus infection in vitro?
The rigid amphipathic fusion inhibitors aUY11 and cm1UY11 demonstrate potent in vitro antiviral activity against African swine fever virus, representing potential candidates for future therapeutic development.
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Supports advancing rigid amphipathic fusion inhibitors for ASFV; leaves open in vivo efficacy and field applicability in swine.
Hakobyan et al. (2017) studied African swine fever virus (ASFV) infection. Rigid amphipathic fusion inhibitors (aUY11 and cm1UY11) was evaluated on Antiviral activity against ASFV. Rigid amphipathic fusion inhibitors (aUY11 and cm1UY11) displayed a potent, dose-dependent inhibitory effect on African swine fever virus infection in Vero cells and porcine alveolar macrophages.
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