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We previously established an epithelial/hybrid cell line, NPC-KT, by fusion 8-azaguanineresistant epithelial cells, Ad-AH, with a primary nasopharyngeal carcinoma cells. Virus preparations (NPC virus) from NPC-KT cells can transform human B-lymphocytes and superinfect Raji cells. In addition, the treatment of NPC virus-superinfected Raji cells with 1% dimethyl sufoxiside led to early antigen and virus DNA synthesis, and the formation of virus particles. The virus rescued from the superinfected Raji cells transforms human cord blood lymphocytes but is not able to induce early antigen in superinfected Raji cells.
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Takimoto et al. (1987) studied this question.
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