Key result
Each year of CRT delay after a first HFH is linked to ~15% higher mortality.
Why the study?
The optimum timing of cardiac resynchronization therapy implantation is unknown.
Does delayed cardiac resynchronization therapy (CRT) implantation after a first heart failure hospitalization worsen long-term clinical outcomes?
Cohort (n=64,968)
Yes
Does delayed cardiac resynchronization therapy (CRT) implantation after a first heart failure hospitalization worsen long-term clinical outcomes?
Hazard Ratio: 1.15 (95% CI 1.14–1.16)
Delays from a first heart failure hospitalization to CRT implantation are associated with progressively worse long-term clinical outcomes, suggesting early implantation is beneficial.
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Earlier CRT after first HFH may reduce mortality and HFH; leaves open whether prospective trials should test earlier implantation strategies.
Leyva et al. (2023) conducted a cohort in Heart failure (n=64,968). Delay from first heart failure hospitalization to CRT implantation vs. No previous heart failure hospitalization was evaluated on Total mortality (HR 1.15, 95% CI 1.14-1.16). Each year of delay from a first heart failure hospitalization to cardiac resynchronization therapy implantation was associated with a higher risk of total mortality (HR 1.15; 95% CI 1.14-1.16).
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