Key result
Guinea pig pregnancy induces significantly increased expression of cardiac ventricular ADBR1, INSR, and S1P1R compared to non-pregnant controls (P<0.05).
Population
Guinea pig hearts (non-pregnant and late pregnant Day 68, n=6)
Comparison
Late pregnancy (Day 68) vs Non-pregnant state
Design
Preclinical
Authors
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Supports guinea pig as model for pregnancy cardiac remodeling; leaves open human translation.
p-value: p=<0.05
The guinea pig is proposed as a superior preclinical model for human pregnancy-induced cardiac remodeling, supported by preliminary data showing upregulation of key receptors (ADRB1, INSR, S1P1R).
Taggart et al. (2014) conducted a letter in Pregnancy-induced cardiac remodelling (n=6). Pregnancy vs. Non-pregnancy was evaluated on Expression of cardiac ventricular ADBR1, INSR, and S1P1R (p=<0.05). Guinea pig pregnancy induces significantly increased expression of cardiac ventricular ADBR1, INSR, and S1P1R compared to non-pregnant controls (P<0.05).
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