Key result
Pregnancy in the guinea pig increased cardiac output by 32% (P<0.05) and stroke volume by 46% (P<0.025) without changes in left ventricular mass, morphometry, or elastic modulus.
Population
Time-bred virgin guinea pigs paired by weight with unbred controls
Comparison
Pregnancy vs Unbred control guinea pigs
Design
Preclinical
Follow-up
Days 59-68 of gestation
Authors
Loading...
Pregnancy boosts guinea pig cardiac output via stroke volume without LV remodeling; leaves open translation to human peripartum adaptation.
Effect estimate: +32% increase
p-value: p=<0.05
In a guinea pig model, pregnancy increases left ventricular output, stroke volume, and size without altering LV mass, morphometry, or elastic modulus.
Morton et al. (1984) studied Pregnancy. Pregnancy vs. Unbred controls was evaluated on Cardiac output (+32% increase, p=<0.05). Pregnancy in the guinea pig increased cardiac output by 32% (P<0.05) and stroke volume by 46% (P<0.025) without changes in left ventricular mass, morphometry, or elastic modulus.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: