Key result
The stoichiometry of atrial natriuretic factor binding to the R1 receptor was shown to be 1:2, with ANF interacting with both receptor subunits to cross-link a dimeric form of the receptor.
Population
Bovine zona glomerulosa (preclinical model)
Design
Preclinical
Authors
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ANF-R1 dimer cross-linking is confined to bovine adrenal membranes; leaves open whether this stoichiometry modulates human natriuretic signaling.
This preclinical study demonstrates that the atrial natriuretic factor binds to its R1 receptor in a 1:2 stoichiometric ratio, interacting with both subunits of a dimeric receptor.
Rondeau et al. (1995) studied this question. Amiloride and ATP was evaluated on Stoichiometry of ANF binding to the R1 receptor. The stoichiometry of atrial natriuretic factor binding to the R1 receptor was shown to be 1:2, with ANF interacting with both receptor subunits to cross-link a dimeric form of the receptor.
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